Sign, Symptoms and diagnosis of brain tumor
>> Sunday, May 10, 2009
A chronic headache with nausea and vomitting is not a matter to take casually, as the incidence of brain cancer is increasing now a days, a proper knowledge about brain tumor, types of brain tumor and its mode of spread should be known. Details about the brain tumor and its type is given at An overview of brain tumor.
The sign and symptoms depends on the type of tumor and its location, mainly the symptoms are related to the pressure created intracranially due to the mass present.
Symptoms of brain tumors
Absent of any symptoms does not rule out any tumor, that doesnt mean one should regularly undergo a CT or MRI to see that but this is for an information that all tumors under go a silent period, then occurs focal symptoms, then symptoms due to raised intracranial pressure and lastly there may be brain displacement if the tumor grows large enough.
Initial period of silent growth
The initial silent period where there is no sign and symptoms varies in length of period according to position and rate of growth of tumor. For example if the tumor is in free space or an area where there is no structure nearby may have a longer silent period while a tumor near an structure like hypophysis or 4th ventricle may have lesser period.
Stage of focal syndromes
Stage of focal syndrome includes symptoms like seizures or fits. Epileptic fits or seizures first time in adult life should always be suspected due to tumor unless it is dissaproved, because more than 90 percent of idiopathic epilepsy occurs before the age of 30 years, so any seizure detected first time after 30 years should always be suspected for a brain tumor. As now a days we have advanced mode of diagnosis in the form of CT scan and MRI, small tumor like angiomas should be looked for even there is more probability od idiopathic epilepsy.
A steady and slow progression of focal syndrome is also indicative of tumors, though focal syndromes can also be seen in demyelination like in multiple sclerosis, any embolus etc.
Sign and symptoms due to raised intracranial pressure
Rise in intracranial pressure is due to space occupied by the mass which ompresses normal structure of the brain. The symptoms of brain tumor due to increased pressure is headache, vomitting, detoriation in the level of consciousness and even detoriation of visual equity.
The signs are lowered level of consciousness, increased blood pressure, slow pulse rate and papilledema. Papilledema is the swelling of eye lids and can be seen when there is large mass.
Symptoms due to brain displacement
When the tumor is enlarged enough, it occupies most of the place within the brain, displacing the normal structure. This stage is aslo called stage of coning. There may be herniation in cerebellar region and the symptoms depends on the part involved like ataxia, tremor etc. The consciousness level is extremely poor as the intracranial pressure is too high.
Investigation of brain tumor
Before going for an investrigation a proper history is very much indicative even it can give a hint for the site of brain tumor. If symptoms are of long standing it indicates a favorable tumor.
A proper clinical examination including neurological examination is done of all the cranial nerves. Though CT scan and MRI are the main investigations but some accessory investigations is done which is also very indicative for example a raised ESR may indicate a secondary tumor.
CT Scan
CT scan provides reliable information for the presence of a tumor in brain, by intravenous contrast enhancement it can also distinguish the type of tumor, however certain differentiation between a malignant tumor and an abscess may not be possible.
Magnetic Resonance Imaging (MRI)
MRI is the powerful tool to diagnose brain tumors. It is helpful in diagnosing almost all variety of brain tumors, however, the majority of patients, and especially those with supratentorial tumors, can be managed by using CT of which the quality has steadily improved.
Positron emission tomography (PET)
It uses short life isotopes. PET is developing as an investigation of the function of the parts of the brain.
Arteriography
Arteriography is done to see the blood circulation of the pathological tumors specially meningioma and glioblastoma multiforme.
Ventriculography
Ventriculography is valuable for posterior fossa tumor and 3rd ventricle tumor of the brain.
Accessory investigations
Accessory investigations include X ray chest which may diagnose lung cancer in which secondary brain tumor is most common, a skull x ray may show erosions and separation of sutures due to heavy mass in the brain.
Surgery is the mainstay of treatment of brain cancer, as mentioned above a slow progressing tumor is favorable. An early diagnosis may lead to almost full cure in most of the primary brain tumor. Details of treatment is given at Treatment of brain tumors. Read more...

